Kinetic analysis of sequential metabolism of triazolam and its extrapolation to humans using an entero-hepatic two-organ microphysiological system

Published: 14/01/2020
Kinetic analysis of sequential metabolism of triazolam and its extrapolation to humans using an entero-hepatic two-organ microphysiological system
Source: FEEDS.RSC.ORG

Lab Chip , 2020, Advance Article DOI : 10.1039/C9LC00884E, Paper Hiroshi Arakawa, Shinji Sugiura, Takumi Kawanishi, Kazumi Shin, Hiroko Toyoda, Taku Satoh, Yasuyuki Sakai, Toshiyuki Kanamori, Yukio Kato We have constructed a mechanism-based pharmacokinetic model for triazolam and its metabolites in the entero-hepatic two-organ MPS, and extrapolated the kinetic information obtained with the MPS to

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