Inactivation of the indole-diterpene biosynthetic gene cluster of Claviceps paspali by Agrobacterium -mediated gene replacement

Published: 14/03/2018
Inactivation of the indole-diterpene biosynthetic gene cluster of Claviceps paspali by Agrobacterium -mediated gene replacement
Source: LINK.SPRINGER.COM

Abstract The hypocrealean fungus Claviceps paspali is a parasite of wild grasses. This fungus is widely utilized in the pharmaceutical industry for the manufacture of ergot alkaloids, but also produces tremorgenic and neurotoxic indole-diterpene (IDT) secondary metabolites such as paspalitrems A and B. IDTs cause significant losses in agriculture and represent health hazards that threaten food sec

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